PUBLICATIONS

50. M. Bairwa,† A. Shukla,†D. Singh, K. D. Dubey, S. M. Husain Structure Guided Engineering of Enantiocomplementary Imine Reductase Variants Green Chemistry, 2026, Accepted

49. A. Rabbani,† P. Das,† M. Müller S. M. Husain Azo (N=N) Bond Reduction by Ene Reductases ChemComm, 2026, DOI: https://doi.org/10.1039/d6cc04167a

48. D. Gupta, J. Mondal, A. Azim, S. M. Husain, M. Gurjar, B. Poddar Serum Thiols as Biomarkers for Outcome Prediction in Critically Ill Patients: A Prospective Observational Study Indian J Crit Care Med 2026; 30 (S1):S66-S66. DOI: 10.5005/jaypee-journals-10071-25142.66

47. T. Zhana, J. Breiltgensb, L. Appela, L. Pellera, S. M. Husain, M. Müller and M. Boll* Oxygen-independent enzymatic dearomatization of homocyclic aromatic compounds Natural Product Reports 2026, Accepted

46. A. K. Singh, P. Das, J. Mondal, Z. Subzposh, S. M. Husain* A Nitroreductase from Cedecea sulfonylureivorans: Identification, Characterization, and Biocatalytic Potential Catalysis Science and Technology 2026, 16 (13): 4317–4322. DOI: https://doi.org/10.1039/d6cy00168h

45. J. Mondal, A. Azim, S. M. Husain* Enzyme–Coupled Fluorescence Assays for The Detection and Quantification of Amino Acids ChemBioChem 2026, 27, 8, e70352. DOI: https://doi.org/10.1002/cbic.70352

44. T. Manna,+ A. De,+ A. Shukla,+ K. Nurjamal, M. Bairwa, J. Mondal, S. M. Husain* Biocatalytic Asymmetric Synthesis of Diversely Substituted Dihydro-1,4-2H-Benzoxazines and Benzothiazines Chemistry-An Asian Journal 2026, 21, 4 e70644

DOI: https://doi.org/10.1002/asia.70644

43. J. Mondal, P. Das, S. M. Husain* Alternative Dehydrogenases to Address Glucose Dehydrogenase Cross-Reactivity during NADPH Regeneration Chemistry-An Asian Journal 2025, 20, 21, e00654, DOI: https://doi.org/10.1002/asia.202500654

42. P. Das,+ S. Mondal,+ M. Bairwa, J. Mondal, S. M. Husain* Stereodivergent Synthesis of Diversely Substituted Dibenzoxazepines using Imine Reductases Organic Letters 2025, 27, 26, 6989–6994. DOI: https://doi.org/10.1021/acs.orglett.5c01860

41. J. Mondal, P. Das, S. M. Husain* Isocitrate Dehydrogenase from Escherichia coli displays High Solvent Tolerance during NADPH generation Org. & Biomol. Chem. 2025, DOI: https://doi.org/10.1039/D5OB00917K

40. T. Manna, P. Das, A. Rabbani, F. Beyer, C. Merten, S. M. Husain* Biocatalytic Stereodivergent Synthesis of Substituted Tetrahydro-Benzo-(Oxa, Thia, and Di)-Azepines Chem. A Eur J. 2025, e202404537 DOI: https://doi.org/10.1002/chem.202404537

39. A. De, A. Shukla S. M. Husain* One-Pot Multienzyme Cascades for Stereodivergent Synthesis of Tetrahydroquinolines Angew Chem. Inter. Ed. 2024, DOI: https://onlinelibrary.wiley.com/doi/10.1002/ange.202411561

38. A. De, T. Manna, S. C. Debnath, S. M. Husain* Organophotoredox-catalyzed stereoselective reductive dimerization of chromone-2-carboxylic esters New Journal of Chemistry 2024, 48, 1902-1906. DOI: https://doi.org/10.1039/D3NJ05659G

37. A. Rajput, T. Manna, S. M. Husain* Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses Natural Product Reports 2023, 40, 1672-1686. DOI: https://doi.org/10.1039/D3NP00027C

36. A. Rajput, T. Manna, A. Mondal, A. De, J. Mondal, S. M. Husain* Biocatalytic Access to Chiral Benzazepines Using Imine Reductases ACS Catalysis 2023, 13, 9, 6185–6194. DOI: https://doi.org/10.1021/acscatal.3c00146

35. A. Mondal, N. Saha, S. M. Husain* Concise chemoenzymatic total synthesis of (−)-rubroskyrin, (−)-deoxyrubroskyrin (−)-luteoskyrin, and (−)-deoxyluteoskyrin Tetrahedron Chem. 2022, 3, 100030. DOI: https://doi.org/10.1016/j.tchem.2022.100030

34. T. Manna, A. De, K. Nurjamal, S. M. Husain* Asymmetric synthesis of (+)-teratosphaerone B, its non-natural analogue and (+)-xylarenone using an ene- and naphthol reductase cascade Org. & Biomol. Chem. 2022, 20, 7410- 7414. DOI: https://doi.org/10.1039/D2OB01262F

33. A. De,+ N. Saha,+ T. Manna, V. Singh, S. M. Husain* Highly Efficient One-Pot Multienzyme Cascades for the Stereoselective Synthesis of Natural Naphthalenones ACS Catalysis 2022, 12, 19, 12179-12185. DOI: https://doi.org/10.1039/D2OB00401A +equal contributions

32. T. Manna, A. Rajput, N. Saha, A. Mondal, S. C. Debnath, S. M. Husain* Chemoenzymatic Total Synthesis of Nodulones C & D using a Naphthol Reductase of Magnaporthe grisea Org. & Biomol. Chem. 2022, 20, 3737 - 374. DOI: https://doi.org/10.1039/D2OB00401A First appeared on Chemarxiv 2021, DOI: https:10.26434/chemrxiv-2021-3hr0t

31. A. Rajput, A. De, A. Mondal, K. Das, B. Maity, S. M. Husain* A Biocatalytic Approach towards the Preparation of Natural Deoxyanthraquinones and their Impact on Cellular Viability New J. Chem 2022, 46, 3087-3090 DOI: https://doi.org/10.1039/D1NJ05513E

30. A. Rajput, A. Mondal, S. K. Pandey, S. M. Husain* Synthesis of rhein and diacerein: a chemoenzymatic approach using anthrol reductase of Talaromyces islandicus Org. & Biomol. Chem. 2022, 20, 358-361. DOI: https://doi.org/10.1039/D1OB02202D

29. T. Manna, A. Rajput, N. Saha, A. Mondal, S. M. Husain* Asymmetric Synthesis of Nodulones C & D by Chemoenzymatic Approach gives Insight into their Biosynthesis Chemarxiv 2021, DOI: https://chemrxiv.org/engage/chemrxiv/article-details/614980ad1df4a1749a76a858

28. S. K. Singh, A. Rajput, Arijit De, T. Chakraborti S. M. Husain* Promiscuity of an Unrelated Anthrol Reductase of Talaromyces islandicus WF-38-12 Cat. Sci. & Technology 2021, 11, 474-478. DOI: https://doi.org/10.1039/D0CY02148B

27. A. Modal, Arijit De, S. M. Husain* Synthesis of (‒)-Flavoskyrins by Catalyst Free Oxidation of (R)-Configured Dihydroanthracenones in Aqueous Media and its (Bio)synthetic Implications Organic Letters 2020, 22, 8511-8515. DOI: 10.1021/acs.orglett.0c03121

26. S. K. Singh, A. Mohammad, O. A. Alghamdi, S. M. Husain* New Approaches for targeting drug resistance through drug combination Book Chapter in Combination Therapy Against Multidrug Resistance 2020 Edited by M. Y. Wani & A. Ahmed Published by Elsevier (978-0-12-820576-1)

25. A. Mondal,+ S. K. Singh,+ N. Saha, S. M. Husain* Synthesis of Racemic Dihydroanthracen-1(2H)-ones using Sodium Borohydride in Water Eur J. Org. Chem. 2020, 2425-2430. DOI: 10.1002/ejoc.202000096 Very Important Paper

24. A. Mondal, S. K. Singh, T. Manna, S. M. Husain* Chemoenzymatic, Biomimetic Total Synthesis of (‒)-Rugulosin B, C and Rugulin Analogues and its Biosynthetic Implications ChemComm 2020, 56, 3337-3340. DOI: 10.1039/D0CC00406E

23. S. K. Singh,+ A. Mondal,+ N. Saha, S. M. Husain* Identification and Characterization of an Anthrol Reductase from Talaromyces islandicus (Penicillium islandicum) WF-38-12 Green Chemistry 2019, 21, 6954-6959. DOI: 10.1039/C9GC03072G

22. S. M. Husain,+ A. Präg,+A. Linnenbrink, A. Bechthold, M. Müller Insights into the Role of Ketoreductases in the Biosynthesis of Partially Reduced Bacterial Aromatic Polyketides ChemBioChem 2020, 21, 780-784. DOI: https://doi.org/10.1002/cbic.201900357

21. A. Mondal,+ N. Saha,+ A. Rajput, S. K. Singh, B. Roy, S. M. Husain* Chemoenzymatic Reduction of Citreorosein and its Implications for Aloe-Emodin and Rugulosin C (Bio)synthesis Org. Biomol. Chem. 2019, 17, 8711-8715. DOI: 10.1039/C9OB01690B

20. N. Saha, M. Müller, S. M. Husain* Asymmetric Synthesis of Natural cis-Dihydroarenediols Using Tetrahydroxynaphthalene Reductase and Its Biosynthetic Implications Org. Lett. 2019, 21, 2204-2208.

19. S. K. Singh, S. M. Husain* A Redox-based Superoxide Generation System using Quinone/Quinone Reductase

ChemBioChem 2018, 19, 1657-1663.

18. N. Saha+, A. Mondal+, K. Witte, S. K. Singh, M. Müller, S. M. Husain* Monomeric Dihydroanthaquinones: A Chemoenzymatic Approach and its (Bio)synthetic Implications for Bisnathraquinones Chem. Eur. J. 2018, 24, 1283-1286. +equal contribution

17. S. M. Husain, M. Müller* Fungal Dihydroxynaphthalene-Melanin: Diversity-Oriented Biosynthesis through Enzymatic and Nonenzymatic Transformations Synlett 2017, 28, 2360-2372.

16. L. Fürtges, D. Conradt, M. A. Schaetzle, S. K. Singh, N. Kraševec, T. L. Rižner, M. Müller,* S. M. Husain* Phylogenetic Studies, Gene Cluster Analysis, and Enzymatic Reaction Support Anthrahydroquinone Reduction as the Physiological Function of Fungal 17beta-Hydroxysteroid Dehydrogenase ChemBioChem 2016, 18, 77-80. [Link]

15. J. Haas, M. A. Schätzle, S. M. Husain, J. Schulz-Fincke, M. Jung, W. Hummel, M. Müller, S. Lüdeke A quinone mediator drives oxidations catalysed by alcohol dehydrogenase-containing cell lysates Chem. Comm. 2016, 52, 5198-5201.

14. M. A. Schätzle, S.M. Husain, M. Müller Tetrahydroxynaphthalene Reductase – Catalytic Properties of an Enzyme Involved in Reductive Asymmetric Naphthol Dearomatization Book Chapter in Practical Methods for Biocatalysis and Biotransformations-3- 2016 Edited by Whitall, Sutton, and Kroutil

13. D. Conradt, M. A. Schätzle, S.M. Husain, M. Müller Diversity in Reduction with Short-Chain Dehydrogenases: Tetrahydroxynaphthalene Reductase, Trihydroxynaphthalene Reductase, and Glucose Dehydrogenase Chem.Cat. Chem. 2015, 7, 3116-3120.

12. S.M. Husain, M. A. Schätzle, S. Lüdeke, M. Müller Unprecedented Role of Hydronaphthoquinone Tautomers in Biosynthesis Angew. Chem. Int. Ed. 2014, 53, 9806-9811.

Mentored Publications

11. M. A. Schätzle, S. M. Husain, S. Ferlaino, M. Müller Tautomers of Anthrahydroquinones: Enzymatic Reduction and Implications for Chrysophanol, Monodictyphenone, and Related Xanthone Biosyntheses J. Am. Chem. Soc. 2012, 134, 14742-14745. [PDF] [Supporting info]

10. S. M. Husain, M. A. Schätzle, C. Röhr, S. Lüdeke, M. Müller Biomimetic Asymmetric Synthesis of (R)-GTRI-02 and (3S,4R)-3,4-Dihydroxy-3,4-dihydronaphthalene-1(2H)-ones Org. Lett. 2012, 14, 3600-3603. [PDF] [Supporting info]

9. J. Kulig, R. C. Simon, C. A. Rose, S. M. Husain, M. Häckh, S. Lüdeke, K. Zeitler, W. Kroutil, M. Pohl, D. Rother Stereoselective synthesis of bulky 1,2-diols with alcohol dehydrogenases Catal. Sci. Technol. 2012, 2, 1580-1589.[PDF] [Supporting info]

8. M. A. Schätzle, S. Flemming, S.M. Husain, M. Richter, S. Günther, M. Müller Tetrahydroxynaphthalene Reductase – Catalytic Properties of an Enzyme involved in Reductive Asymmetric Naphthol Dearomatization Angew. Chem. Int. Ed. 2012, 51, 2643-2646. [PDF] [Supporting info]

7. S. M. Husain,T. Stillger, P. Dünkelmann, M. Lödige, L. Walter, E. Breitling, M. Pohl, M. Bürchner,I. Krossing, M. Müller, D. Romano,F. Molinari Stereoselective reduction of 2-hydroxy ketones towards syn– and anti-1,2-Diols Adv. Synth. Catal. 2011, 353, 2359-2362. [PDF] [Supporting info]

From Ph.D.

6. S. Sarkar, S. M. Husain, D. Schepmann, R. Fröhlich, B. Wünsch Microwave assisted synthesis of 3-benzazepin-2-ones as building blocks for 2,3-disubstituted tetrahydro-3-benzazepines Tetrahedron 2012, 68, 2687-2695.[PDF]

5. S. M. Husain, R. Fröhlich, D. Schepmann, B. Wünsch Enantioselective Synthesis of a 2,2-Disubstituted Tetrahydro-3-benzazepine as Novel Receptor Antagonist Z. Naturforsch. 2010, 65b, 191-196.
[PDF]

4. Asymmetric Synthesis and σ receptor affinity of enantiomerically pure 1,4-disubstituted-tetrahydro-1H-3-benzazepines
S. M. Husain, M. T. Heim, D. Schepmann, B, Wünsch, Tetrahedron: Asymmetry, 2009, 20, 1383-1392.
[PDF]

3. S.M. Husain, R. Fröhlich, D. Schepmann, B. Wünsch Asymmetric Synthesis of Enantiomerically pure 2-Substituted-3-benzazepines and Their Affinity to σ1 Receptors J. Org. Chem. 2009, 74, 2788-2793.
[PDF] [Supporting Info]

2. S. M. Husain, R. Fröhlich, B. Wünsch A very short asymmetric synthesis of enantiomerically pure methyl substituted tetrahydro-3-benzazepines Tetrahedron: Asymmetry, 2008, 19, 1613-1616.
[PDF]

1. S. M. Husain, B. Wünsch, Synthesis of Phenylacetic Acids with 2-Oxoalkyl Substituents in ortho-Position from o-Phenylenediacetic Acid Synthesis, 2008, 17, 2729-2732.